Silvia Sacchi Selected Research

D-Amino-Acid Oxidase (D-Amino Acid Dehydrogenase)

1/2021	An antibody-based enzymatic therapy for cancer treatment: The selective localization of D-amino acid oxidase to EDA fibronectin.
11/2017	Understanding renal nuclear protein accumulation: an in vitro approach to explain an in vivo phenomenon.
12/2015	High-Throughput Screening Strategy Identifies Allosteric, Covalent Human D-Amino Acid Oxidase Inhibitor.
3/2013	Characterization of human DAAO variants potentially related to an increased risk of schizophrenia.
1/2013	D-amino acid oxidase inhibitors as a novel class of drugs for schizophrenia therapy.
11/2011	Is rat an appropriate animal model to study the involvement of D-serine catabolism in schizophrenia? Insights from characterization of D-amino acid oxidase.
9/2011	Evidence for the interaction of D-amino acid oxidase with pLG72 in a glial cell line.
8/2010	Effect of ligand binding on human D-amino acid oxidase: implications for the development of new drugs for schizophrenia treatment.
4/2009	Relevance of weak flavin binding in human D-amino acid oxidase.
8/2008	pLG72 modulates intracellular D-serine levels through its interaction with D-amino acid oxidase: effect on schizophrenia susceptibility.

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Silvia Sacchi Research Topics

Disease

22	Schizophrenia (Dementia Praecox) 01/2021 - 03/2006
7	Glioblastoma (Glioblastoma Multiforme) 01/2021 - 08/2008
6	Mental Disorders (Mental Disorder) 01/2021 - 03/2006
6	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 07/2018
3	Neoplasms (Cancer) 01/2021 - 02/2008
2	Brain Diseases (Brain Disorder) 01/2021 - 07/2018
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 06/2020 - 07/2018
2	Overactive Urinary Bladder (Overactive Bladder) 11/2017 - 01/2017
2	Pathologic Processes 01/2017 - 08/2012
1	Microcephaly 12/2020
1	Seizures (Absence Seizure) 12/2020
1	Dyskinesias (Dyskinesia) 01/2019
1	Parkinson Disease (Parkinson's Disease) 01/2019
1	Pain (Aches) 07/2018
1	DiGeorge Syndrome (Syndrome, DiGeorge) 01/2018
1	Mood Disorders (Mood Disorder) 05/2016
1	Central Nervous System Diseases (CNS Diseases) 09/2015
1	Cocaine-Related Disorders (Cocaine Addiction) 04/2013
1	Neurobehavioral Manifestations 01/2013
1	Epilepsy (Aura) 11/2012
1	Bipolar Disorder (Manic Depressive Psychosis) 11/2012
1	Shellfish Poisoning 06/2000

Drug/Important Bio-Agent (IBA)

24	Serine (L-Serine)FDA Link 01/2021 - 04/2006
12	D-Amino-Acid Oxidase (D-Amino Acid Dehydrogenase)IBA 01/2021 - 03/2006
8	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2021 - 04/2009
7	Proteins (Proteins, Gene)FDA Link 01/2021 - 09/2011
6	EnzymesIBA 01/2021 - 02/2008
4	D-Aspartic Acid (D Aspartate)IBA 01/2021 - 01/2017
3	Neurotransmitter Agents (Neurotransmitter)IBA 01/2021 - 09/2011
3	Amino Acids FDA Link 12/2020 - 01/2012
3	N-Methylaspartate (NMDA)IBA 02/2014 - 04/2006
2	Glutamic Acid (Glutamate)FDA Link 01/2021 - 01/2018
2	Messenger RNA (mRNA)IBA 01/2019 - 01/2018
2	propiverineIBA 11/2017 - 01/2017
2	Pharmaceutical PreparationsIBA 11/2017 - 01/2017
2	Antipsychotic Agents (Antipsychotics)IBA 10/2017 - 01/2013
2	serine racemaseIBA 01/2017 - 01/2013
2	Glutamate Receptors (Glutamate Receptor)IBA 11/2011 - 04/2006
1	Protein Isoforms (Isoforms)IBA 01/2021
1	F8 monoclonal antibodyIBA 01/2021
1	Dopamine (Intropin)FDA LinkGeneric 01/2021
1	Fibronectins (Fibronectin)IBA 01/2021
1	Peptides (Polypeptides)IBA 01/2021
1	ProdrugsIBA 01/2021
1	Biomarkers (Surrogate Marker)IBA 01/2021
1	Heme Oxygenase-1IBA 01/2021
1	Superoxides (Superoxide)IBA 06/2020
1	CaspasesIBA 06/2020
1	Levodopa (L Dopa)FDA LinkGeneric 01/2019
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2019
1	Proline Oxidase (Proline Dehydrogenase)IBA 01/2018
1	Glutamine (L-Glutamine)FDA Link 01/2018
1	Proline (L-Proline)FDA Link 01/2018
1	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 11/2017
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 11/2017
1	Haloperidol (Haldol)FDA LinkGeneric 10/2017
1	Clozapine (Clozaril)FDA LinkGeneric 10/2017
1	Chlorpromazine (Thorazine)FDA Link 10/2017
1	Bupropion (Wellbutrin)FDA LinkGeneric 10/2017
1	Amitriptyline (Elavil)FDA LinkGeneric 10/2017
1	Olanzapine (Zyprexa)FDA Link 10/2017
1	Fluoxetine (Prozac)FDA LinkGeneric 10/2017
1	A-factor (Streptomyces)IBA 01/2017
1	D-Aspartate OxidaseIBA 01/2017
1	Aspartic Acid (Aspartate)FDA Link 01/2017
1	ElementsIBA 05/2016
1	Genetic Markers (Genetic Marker)IBA 05/2016
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 02/2014
1	Cyan Fluorescent ProteinIBA 02/2014
1	Protein AggregatesIBA 03/2013
1	Flavin-Adenine Dinucleotide (FAD)IBA 01/2013
1	LigandsIBA 08/2010
1	FlavoproteinsIBA 04/2009
1	cephalosporin CIBA 02/2008
1	Cephalosporins (Cephalosporin Antibiotics)IBA 02/2008
1	SaxitoxinIBA 06/2000

Therapy/Procedure

3	Therapeutics 01/2021 - 01/2013
2	Oral Administration 01/2019 - 01/2013